| Tissue Specificity | Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes. |
| Post Translational Modifications | Phosphorylation is required for binding to YWHAZ. |
| Function | Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. |
| Protein Name | Myeloid Leukemia Factor 1Myelodysplasia-Myeloid Leukemia Factor 1 |
| Cellular Localisation | CytoplasmNucleusCell ProjectionCiliumCytoskeletonCilium Basal BodyShuttles Between The Cytoplasm And Nucleus |
| Alternative Antibody Names | Anti-Myeloid Leukemia Factor 1 antibodyAnti-Myelodysplasia-Myeloid Leukemia Factor 1 antibodyAnti-MLF1 antibody |
Information sourced from Uniprot.org
