Anti-MKRN2 antibody (STJA0007740)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human MKRN2
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase makorin-2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MKRN2 |
| Gene ID | 23609 |
| Uniprot ID | MKRN2_HUMAN |
| Immunogen | Synthesized peptide derived from human MKRN2 |
| Specificity | This antibody detects endogenous levels of MKRN2 at Human, Mouse |
Additional Info
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses. Plays a role in the regulation of spermiation and in male fertility. |
| Protein Name | E3 Ubiquitin-Protein Ligase Makorin-2Ring Finger Protein 62Ring-Type E3 Ubiquitin Transferase Makorin-2 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Makorin-2 antibodyAnti-Ring Finger Protein 62 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Makorin-2 antibodyAnti-MKRN2 antibodyAnti-RNF62 antibodyAnti-HSPC070 antibody |
Information sourced from Uniprot.org