Anti-MKP1 antibody (1-172 aa) (STJ11105073)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MKP1 (1-172 aa) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Dusp1 |
| Gene ID | 19252 |
| Uniprot ID | DUS1_MOUSE |
| Immunogen Region | 1-172 aa |
| Immunogen Sequence | MVMEVGILDAGGLRALLREG AAQCLLLDCRSFFAFNAGHI AGSVNVRFSTIVRRRAKGAM GLEHIVPNAELRGRLLAGAY HAVVLLDERSASLDGAKRDG TLALAAGALCREARSTQVFF LQGGYEAFSASCPELCSKQS TPTGLSLPLSTSVPDSAESG CSSCSTPLYDQG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of mouse MKP1. (NP_038670.1). |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation. 'Lys-48'-linked polyubiquitinated by NEURL3, leading to proteasomal degradation. |
| Function | Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. |
| Protein Name | Dual Specificity Protein Phosphatase 1Mitogen-Activated Protein Kinase Phosphatase 1Map Kinase Phosphatase 1Mkp-1Protein-Tyrosine Phosphatase 3ch134Protein-Tyrosine Phosphatase Erp |
| Database Links | Reactome: R-MMU-112409Reactome: -MMU-5675221 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 1 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 1 antibodyAnti-Map Kinase Phosphatase 1 antibodyAnti-Mkp-1 antibodyAnti-Protein-Tyrosine Phosphatase 3ch134 antibodyAnti-Protein-Tyrosine Phosphatase Erp antibodyAnti-Dusp1 antibodyAnti-3ch134 antibodyAnti-Mkp1 antibodyAnti-Ptpn10 antibodyAnti-Ptpn16 antibody |
Information sourced from Uniprot.org