Anti-Mitochondrial uncoupling protein 3 antibody (C-Term) (STJA0040690)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenA peptide from the C-terminus of human Uncoupling Protein 3 (298-312 aa).
General Information
| Short Description | Chicken polyclonal anti-Mitochondrial uncoupling protein 3 (C-Term) for use in WB in Human, Mouse, Pig and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Chicken |
| Reactivity | Human/Mouse/Pig/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Purification | Affinity-purified |
| Dilution Range | WB 1:1000-1:5000 |
| Formulation | PBS with 0.02% sodium azide. |
| Storage Instruction | Short term storage at 2-8°C for one week. At-20°C as an undiluted liquid for up to 12 months. |
Target Information
| Gene Symbol | UCP3 |
| Gene ID | 7352 |
| Uniprot ID | UCP3_HUMAN |
| Immunogen | A peptide from the C-terminus of human Uncoupling Protein 3 (298-312 aa). |
| Immunogen Region | C-Term |
| Immunogen Sequence | Human |
| Specificity | This antibody detects UCP3 at approx 35 kDa. Human, mouse, rat, Porcine. |
Additional Info
| Tissue Specificity | Only in skeletal muscle and heart. Also expressed in white and brown adipose tissues. Is more expressed in glycolytic than in oxidative skeletal muscles. |
| Function | Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism. Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis. However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity. |
| Protein Name | Putative Mitochondrial Transporter Ucp3Solute Carrier Family 25 Member 9Uncoupling Protein-3Ucp 3 |
| Database Links | Reactome: R-HSA-167826 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Putative Mitochondrial Transporter Ucp3 antibodyAnti-Solute Carrier Family 25 Member 9 antibodyAnti-Uncoupling Protein-3 antibodyAnti-Ucp 3 antibodyAnti-UCP3 antibodyAnti-SLC25A9 antibody |
Information sourced from Uniprot.org