Anti-Mitochondrial Fission 1 Protein antibody [R06-8J2] (STJA0037004)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human TTC11
General Information
| Short Description | Rabbit monoclonal anti-Mitochondrial Fission 1 Protein for use in WB, IHC-P, ICC and IF in Human and Cow samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R06-8J2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | FIS1 |
| Gene ID | 51024 |
| Uniprot ID | FIS1_HUMAN |
| Immunogen | A synthesized peptide derived from human TTC11 |
Additional Info
| Post Translational Modifications | Ubiquitinated by MARCHF5. |
| Function | Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event. Also mediates peroxisomal fission. May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. |
| Protein Name | Mitochondrial Fission 1 ProteinFis1 HomologHfis1Tetratricopeptide Repeat Protein 11Tpr Repeat Protein 11 |
| Database Links | Reactome: R-HSA-9603798 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane ProteinPeroxisome Membrane |
| Alternative Antibody Names | Anti-Mitochondrial Fission 1 Protein antibodyAnti-Fis1 Homolog antibodyAnti-Hfis1 antibodyAnti-Tetratricopeptide Repeat Protein 11 antibodyAnti-Tpr Repeat Protein 11 antibodyAnti-FIS1 antibodyAnti-TTC11 antibodyAnti-CGI-135 antibody |
Information sourced from Uniprot.org