Anti-Mint3 antibody [R03-9F9] (STJA0036316)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human MINA53
General Information
| Short Description | Rabbit monoclonal anti-Mint3 for use in WB, ICC and IF in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-9F9 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | RIOX2 |
| Gene ID | 84864 |
| Uniprot ID | RIOX2_HUMAN |
| Immunogen | A synthesized peptide derived from human MINA53 |
Additional Info
| Tissue Specificity | Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines. |
| Function | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. |
| Protein Name | Ribosomal Oxygenase 260s Ribosomal Protein L27a Histidine HydroxylaseBifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase MinaHistone Lysine Demethylase MinaMyc-Induced Nuclear AntigenMineral Dust-Induced Gene ProteinNucleolar Protein 52Ribosomal Oxygenase MinaRox |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-9629569 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Ribosomal Oxygenase 2 antibodyAnti-60s Ribosomal Protein L27a Histidine Hydroxylase antibodyAnti-Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase Mina antibodyAnti-Histone Lysine Demethylase Mina antibodyAnti-Myc-Induced Nuclear Antigen antibodyAnti-Mineral Dust-Induced Gene Protein antibodyAnti-Nucleolar Protein 52 antibodyAnti-Ribosomal Oxygenase Mina antibodyAnti-Rox antibodyAnti-RIOX2 antibodyAnti-MDIG antibodyAnti-MINA antibodyAnti-MINA53 antibodyAnti-NO52 antibody |
Information sourced from Uniprot.org