Anti-MIIP antibody (279-388) (STJ116627)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MIIP (279-388) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MIIP |
| Gene ID | 60672 |
| Uniprot ID | MIIP_HUMAN |
| Immunogen Region | 279-388 |
| Immunogen Sequence | AHVRVSIPLSILEPPHRYHI HRRKSFDASDTLALPRHCLL GWDIFPPKSEKSSAPRNLDL WSSVSAEAQHQKLSGTSSPF HPASPMQMLPPTPTWSVPQV PRPHVPRQKP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 279-388 of human MIIP (NP_068752.2). |
Additional Info
| Tissue Specificity | Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. |
| Post Translational Modifications | Isoform 2 is degraded by the ubiquitin-proteasome pathway. |
| Function | Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. |
| Protein Name | Migration And Invasion-Inhibitory ProteinIgfbp2-Binding ProteinInvasion-Inhibitory Protein 45Iip45 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Migration And Invasion-Inhibitory Protein antibodyAnti-Igfbp2-Binding Protein antibodyAnti-Invasion-Inhibitory Protein 45 antibodyAnti-Iip45 antibodyAnti-MIIP antibodyAnti-IIP45 antibody |
Information sourced from Uniprot.org