| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Calcium Uptake Protein 1-Mitochondrial (105-255) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MICU1 |
| Gene ID: |
10367 |
| Uniprot ID: |
MICU1_HUMAN |
| Immunogen Region: |
105-255 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 105-255 of human MICU1 (NP_001182447.1). |
| Immunogen Sequence: |
GFRDRKVMEYENRIRAYSTP DKIFRYFATLKVISEPGEAE VFMTPEDFVRSITPNEKQPE HLGLDQYIIKRFDGKKISQE REKFADEGSIFYTLGECGLI SFSDYIFLTTVLSTPQRNFE IAFKMFDLNGDGEVDMEEFE QVQSIIRSQTS |
| Tissue Specificity | Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells. |
| Function | Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. |
| Protein Name | Calcium Uptake Protein 1 - MitochondrialAtopy-Related Autoantigen CalcAra CalcCalcium-Binding Atopy-Related Autoantigen 1Allergen Hom S 4 |
| Database Links | Reactome: R-HSA-8949215Reactome: R-HSA-8949664 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane ProteinMitochondrion Intermembrane Space |
| Alternative Antibody Names | Anti-Calcium Uptake Protein 1 - Mitochondrial antibodyAnti-Atopy-Related Autoantigen Calc antibodyAnti-Ara Calc antibodyAnti-Calcium-Binding Atopy-Related Autoantigen 1 antibodyAnti-Allergen Hom S 4 antibodyAnti-MICU1 antibodyAnti-CALC antibodyAnti-CBARA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
