Anti-Microtubule-associated protein 2 antibody (STJA0040649)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenBovine MAP2 isolated from brain by the GTP microtubule cycling method.
General Information
| Short Description | Chicken polyclonal anti-Microtubule-associated protein 2 for use in ICC, IHC-F, IHC-P and WB in Bovine, Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ICC/IHC-F/IHC-P/WB |
| Host | Chicken |
| Reactivity | Bovine/Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Purification | IgY preparation |
| Dilution Range | WB 1:10000-1:20000IHC 1:5000-1:10000ICC 1:5000-1:10000 |
| Formulation | Lyophilized IgY preparation, with sodium azide. |
| Storage Instruction | Spin vial briefly before opening. Reconstitute with 50 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution of lyophilized antibody, aliquot and store at-20°C for a higher stability. Avoid freeze-tha |
Target Information
| Gene Symbol | MAP2 |
| Gene ID | 4133 |
| Uniprot ID | MTAP2_HUMAN |
| Immunogen | Bovine MAP2 isolated from brain by the GTP microtubule cycling method. |
| Immunogen Sequence | Bovine |
| Specificity | The specificity of this antibody has been confirmed by IC. Hu, rat, Ms, Bov. |
Additional Info
| Post Translational Modifications | Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation. |
| Function | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| Protein Name | Microtubule-Associated Protein 2Map-2 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Microtubule-Associated Protein 2 antibodyAnti-Map-2 antibodyAnti-MAP2 antibody |
Information sourced from Uniprot.org