| Short Description : | Chicken polyclonal anti-Microtubule-associated protein 2 for use in ICC, IHC-F, IHC-P and WB in Bovine, Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | ICC/IHC-F/IHC-P/WB |
| Host: | Chicken |
| Reactivity: | Bovine/Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgY |
| Conjugation: | Unconjugated |
| Purification: | IgY preparation |
| Dilution Range: | WB 1:10000-1:20000IHC 1:5000-1:10000ICC 1:5000-1:10000 |
| Formulation: | Lyophilized IgY preparation, with sodium azide. |
| Storage Instruction: | Spin vial briefly before opening. Reconstitute with 50 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution of lyophilized antibody, aliquot and store at-20°C for a higher stability. Avoid freeze-tha |
| Gene Symbol: | MAP2 |
| Gene ID: | 4133 |
| Uniprot ID: | MTAP2_HUMAN |
| Immunogen: | Bovine MAP2 isolated from brain by the GTP microtubule cycling method. |
| Immunogen Sequence: | Bovine |
| Specificity: | The specificity of this antibody has been confirmed by IC. Hu, rat, Ms, Bov. |
| Post Translational Modifications | Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation. |
| Function | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| Protein Name | Microtubule-Associated Protein 2Map-2 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Microtubule-Associated Protein 2 antibodyAnti-Map-2 antibodyAnti-MAP2 antibody |
Information sourced from Uniprot.org
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