Anti-MICA antibody [16A8] {PerCP} (STJA0030559)
SPECIFICATIONS
ClonalityMonoclonal
HostHuman
ConjugationPerCP
IsotypeIgG1k
General Information
| Short Description | Human monoclonal Mhc Class I Polypeptide-Related Sequence A antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Human |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 16A8 |
| Isotype | IgG1k |
| Conjugation | PerCP |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | MICA |
| Gene ID | 100507436 |
| Uniprot ID | MICA_HUMAN |
Additional Info
| Post Translational Modifications | N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation. Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation. Palmitoylated on cysteine residues in the cytoplasmic tail leading to its association with membrane microdomains enriched in cholesterol. N-glycosylation is necessary for cell surface expression. (Microbial infection) Ubiquitinated by human herpesvirus 8 protein K5, leading to degradation. |
| Function | Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells. Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production. |
| Protein Name | Mhc Class I Polypeptide-Related Sequence AMic-A |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmExpressed On The Cell Surface In Gastric EpitheliumEndothelial Cells And Fibroblasts And In The Cytoplasm In Keratinocytes And MonocytesInfection With Human Adenovirus 5 Suppresses Cell Surface Expression Due To The Adenoviral E3-19k Protein Which Causes Retention In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Mhc Class I Polypeptide-Related Sequence A antibodyAnti-Mic-A antibodyAnti-MICA antibodyAnti-PERB11.1 antibody |
Information sourced from Uniprot.org