Anti-MGME1 antibody (STJA0004714)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human MGME1
General Information
| Short Description | Rabbit polyclonal anti-Mitochondrial Genome Maintenance Exonuclease 1 for use in IHC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1.26 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | IHC 1:50-1:200 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | MGME1 |
| Gene ID | 92667 |
| Uniprot ID | MGME1_HUMAN |
| Immunogen | Fusion protein of human MGME1 |
Additional Info
| Function | Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endonuclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. |
| Protein Name | Mitochondrial Genome Maintenance Exonuclease 1 |
| Database Links | Reactome: R-HSA-9913635 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Mitochondrial Genome Maintenance Exonuclease 1 antibodyAnti-MGME1 antibodyAnti-C20orf72 antibodyAnti-DDK1 antibody |
Information sourced from Uniprot.org