Anti-MGAT5 antibody (551-600 aa) (STJ192596)

SKU:
STJ192596

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Alpha-1, 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (551-600 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MGAT5
Gene ID: 4249
Uniprot ID: MGT5A_HUMAN
Immunogen Region: 551-600 aa
Specificity: MGT5A Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 551-600
Function Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. Catalyzes an important step in the biosynthesis of branched, complex-type N-glycans, such as those found on EGFR, TGFR (TGF-beta receptor) and CDH2. Via its role in the biosynthesis of complex N-glycans, plays an important role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration. MGAT5-dependent EGFR N-glycosylation enhances the interaction between EGFR and LGALS3 and thereby prevents rapid EGFR endocytosis and prolongs EGFR signaling. Required for efficient interaction between TGFB1 and its receptor. Enhances activation of intracellular signaling pathways by several types of growth factors, including FGF2, PDGF, IGF, TGFB1 and EGF. MGAT5-dependent CDH2 N-glycosylation inhibits CDH2-mediated homotypic cell-cell adhesion and contributes to the regulation of downstream signaling pathways. Promotes cell migration. Contributes to the regulation of the inflammatory response. MGAT5-dependent TCR N-glycosylation enhances the interaction between TCR and LGALS3, limits agonist-induced TCR clustering, and thereby dampens TCR-mediated responses to antigens. Required for normal leukocyte evasation and accumulation at sites of inflammation. Inhibits attachment of monocytes to the vascular endothelium and subsequent monocyte diapedesis. Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A: Promotes proliferation of umbilical vein endothelial cells and angiogenesis, at least in part by promoting the release of the growth factor FGF2 from the extracellular matrix.
Protein Name Alpha-1 -6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase A
Alpha-Mannoside Beta-1 -6-N-Acetylglucosaminyltransferase V
Glcnac-T V
Gnt-V
Mannoside Acetylglucosaminyltransferase 5
N-Acetylglucosaminyl-Transferase V Cleaved Into - Secreted Alpha-1 -6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase A
Secreted Beta-1 -6-N-Acetylglucosaminyltransferase V
Secreted Gnt-V
Database Links Reactome: R-HSA-9694548
Reactome: R-HSA-975577
Cellular Localisation Golgi Apparatus Membrane
Single-Pass Type Ii Membrane Protein
Secreted Alpha-1
6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase A: Secreted
Alternative Antibody Names Anti-Alpha-1 -6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase A antibody
Anti-Alpha-Mannoside Beta-1 -6-N-Acetylglucosaminyltransferase V antibody
Anti-Glcnac-T V antibody
Anti-Gnt-V antibody
Anti-Mannoside Acetylglucosaminyltransferase 5 antibody
Anti-N-Acetylglucosaminyl-Transferase V Cleaved Into - Secreted Alpha-1 -6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase A antibody
Anti-Secreted Beta-1 -6-N-Acetylglucosaminyltransferase V antibody
Anti-Secreted Gnt-V antibody
Anti-MGAT5 antibody
Anti-GGNT5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance