Anti-MFSD8 antibody (351-400 aa) (STJ192571)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 351-400
General Information
| Short Description | Rabbit polyclonal anti-Major facilitator superfamily domain-containing protein 8 (351-400 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MFSD8 |
| Gene ID | 256471 |
| Uniprot ID | MFSD8_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 351-400 |
| Immunogen Region | 351-400 aa |
| Specificity | MFSD8 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Outward-rectifying chloride channel involved in endolysosomal chloride homeostasis, membrane fusion and function. Conducts chloride currents up to hundreds of picoamperes. Regulates lysosomal calcium content by reducing the lysosomal membrane potential, thereby activating TRPML1 channel and further release of lysosomal calcium ions. Regulates the pH in endolysosomal compartments and may contribute to progressive acidification from endosome to lysosome. Permeable to other halides such as iodide and fluoride ions. |
| Protein Name | Major Facilitator Superfamily Domain-Containing Protein 8Ceroid-Lipofuscinosis Neuronal Protein 7 |
| Database Links | |
| Cellular Localisation | Endosome MembraneMulti-Pass Membrane ProteinLysosome MembraneSorting To Lysosomes Involves Dileucine-Based Motif |
| Alternative Antibody Names | Anti-Major Facilitator Superfamily Domain-Containing Protein 8 antibodyAnti-Ceroid-Lipofuscinosis Neuronal Protein 7 antibodyAnti-MFSD8 antibodyAnti-CLN7 antibody |
Information sourced from Uniprot.org