Anti-MFSD12 antibody (78-128 aa) (STJ195920)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human MFS12 at the amino acid range 78-128
General Information
| Short Description | Rabbit polyclonal anti-Major facilitator superfamily domain-containing protein 12 (78-128 aa) for use in WB, ELISA and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MFSD12 |
| Gene ID | 126321 |
| Uniprot ID | MFS12_HUMAN |
| Immunogen | Synthesized peptide derived from the human MFS12 at the amino acid range 78-128 |
| Immunogen Region | 78-128 aa |
| Specificity | This antibody detects endogenous levels of MFS12 at Human/Mouse |
Additional Info
| Post Translational Modifications | Phosphorylation at Thr-254 by MTOR via mTORC1 pathway promotes cysteine transport in lysosomes, thereby regulating lysosomal cysteine and cystine storage and redox homeostasis. |
| Function | Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation. In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin pigmentation. Also catalyzes import of cysteine into lysosomes in non-pigmented cells, regulating lysosomal cystine and cysteine storage, which is essnetial for redox homeostasis. |
| Protein Name | Major Facilitator Superfamily Domain-Containing Protein 12 |
| Database Links | |
| Cellular Localisation | Melanosome MembraneMulti-Pass Membrane ProteinLysosome Membrane |
| Alternative Antibody Names | Anti-Major Facilitator Superfamily Domain-Containing Protein 12 antibodyAnti-MFSD12 antibodyAnti-C19orf28 antibody |
Information sourced from Uniprot.org