Anti-MFGE8 antibody (1-364) (STJ114205)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MFGE8 (1-364) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MFGE8 |
| Gene ID | 4240 |
| Uniprot ID | MFGM_HUMAN |
| Immunogen Region | 1-364 |
| Immunogen Sequence | LDICSKNPCHNGGLCEEISQ EVRGDVFPSYTCTCLKGYAG NHCETKCVEPLGLENGNIAN SQIAASSVRVTFLGLQHWVP ELARLNRAGMVNAWTPSSND DNPWIQVNLLRRMWVTGVVT QGASRLASHEYLKAFKVAYS LNGHEFDFIHDVNKKHKEFV GNWNKNAVHVNLFETPVEAQ YVRLYPTSCHTACTLRFELL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human MFGE8 (NP_005919.2). |
Additional Info
| Tissue Specificity | Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas. |
| Post Translational Modifications | Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273. |
| Function | Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Medin: Main constituent of aortic medial amyloid. |
| Protein Name | LactadherinBreast Epithelial Antigen Ba46HmfgMfgmMilk Fat Globule-Egf Factor 8Mfg-E8Sed1 Cleaved Into - Lactadherin Short Form - Medin |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-977225 |
| Cellular Localisation | MembranePeripheral Membrane ProteinSecretedCytoplasmic VesicleSecretory VesicleAcrosome MembraneLocated In The Acrosomal Region Of Zona-Pellucida Bound Sperm |
| Alternative Antibody Names | Anti-Lactadherin antibodyAnti-Breast Epithelial Antigen Ba46 antibodyAnti-Hmfg antibodyAnti-Mfgm antibodyAnti-Milk Fat Globule-Egf Factor 8 antibodyAnti-Mfg-E8 antibodyAnti-Sed1 Cleaved Into - Lactadherin Short Form - Medin antibodyAnti-MFGE8 antibody |
Information sourced from Uniprot.org