![Anti-MFG-E8/Lactadherin/p47 antibody [MFG-06] (STJ16101070)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149786/346905/STJ16101070_1__46486.1681999088.jpg?c=1 "Anti-MFG-E8/Lactadherin/p47 antibody [MFG-06] (STJ16101070)")
![Anti-MFG-E8/Lactadherin/p47 antibody [MFG-06] (STJ16101070)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149786/346906/STJ16101070_2__93701.1681999089.jpg?c=1 "Anti-MFG-E8/Lactadherin/p47 antibody [MFG-06] (STJ16101070)")
![Anti-MFG-E8/Lactadherin/p47 antibody [MFG-06] (STJ16101070)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149786/346905/STJ16101070_1__46486.1681999088.jpg?c=1 "Anti-MFG-E8/Lactadherin/p47 antibody [MFG-06] (STJ16101070)")
Anti-MFG-E8/Lactadherin/p47 antibody [MFG-06] (STJ16101070)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1K
Immunogenmilk fat globule membrane preparation derived from human breast cancer cell line PMC42
General Information
| Short Description | Mouse monoclonal anti-MFG-E8/Lactadherin/p47 for use in FC, IHC-F, IHC-P, IF and WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IHC-F/IHC-P/IF/WB |
| Host | Mouse |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | MFG-06 |
| Isotype | IgG1K |
| Conjugation | Unconjugated |
| Concentration | 100 Mu g/mL |
| Formulation | PBS with 0.02% sodium azide |
| Storage Instruction | Store at 2-8ยฐC for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | MFGE8 |
| Gene ID | 4240 |
| Uniprot ID | MFGM_HUMAN |
| Immunogen | milk fat globule membrane preparation derived from human breast cancer cell line PMC42 |
Additional Info
| Tissue Specificity | Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas. |
| Post Translational Modifications | Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273. |
| Function | Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Medin: Main constituent of aortic medial amyloid. |
| Protein Name | LactadherinBreast Epithelial Antigen Ba46HmfgMfgmMilk Fat Globule-Egf Factor 8Mfg-E8Sed1 Cleaved Into - Lactadherin Short Form - Medin |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-977225 |
| Cellular Localisation | MembranePeripheral Membrane ProteinSecretedCytoplasmic VesicleSecretory VesicleAcrosome MembraneLocated In The Acrosomal Region Of Zona-Pellucida Bound Sperm |
| Alternative Antibody Names | Anti-Lactadherin antibodyAnti-Breast Epithelial Antigen Ba46 antibodyAnti-Hmfg antibodyAnti-Mfgm antibodyAnti-Milk Fat Globule-Egf Factor 8 antibodyAnti-Mfg-E8 antibodyAnti-Sed1 Cleaved Into - Lactadherin Short Form - Medin antibodyAnti-MFGE8 antibody |
Information sourced from Uniprot.org