Anti-MEX3C antibody (STJA0007768)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human MEX3C
General Information
| Short Description | Rabbit polyclonal anti-RNA-binding E3 ubiquitin-protein ligase MEX3C for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MEX3C |
| Gene ID | 51320 |
| Uniprot ID | MEX3C_HUMAN |
| Immunogen | Synthesized peptide derived from human MEX3C |
| Specificity | This antibody detects endogenous levels of MEX3C at Human, Mouse |
Additional Info
| Function | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. |
| Protein Name | Rna-Binding E3 Ubiquitin-Protein Ligase Mex3cRing Finger And Kh Domain-Containing Protein 2Ring Finger Protein 194Ring-Type E3 Ubiquitin Transferase Mex3c |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleusPredominantly Expressed In The Cytoplasm And Shuttles Between The Cytoplasm And The Nucleus Through The Crm1 Export PathwayMay Act As Suppressor Of Replication Stress And Chromosome Missegregation |
| Alternative Antibody Names | Anti-Rna-Binding E3 Ubiquitin-Protein Ligase Mex3c antibodyAnti-Ring Finger And Kh Domain-Containing Protein 2 antibodyAnti-Ring Finger Protein 194 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Mex3c antibodyAnti-MEX3C antibodyAnti-RKHD2 antibodyAnti-RNF194 antibodyAnti-BM-013 antibody |
Information sourced from Uniprot.org