| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-METTL5 (1-209) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
METTL5 |
| Gene ID: |
29081 |
| Uniprot ID: |
METL5_HUMAN |
| Immunogen Region: |
1-209 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-209 of human METTL5 (NP_054887.2). |
| Immunogen Sequence: |
MKKVRLKELESRLQQVDGFE KPKLLLEQYPTRPHIAACML YTIHNTYDDIENKVVADLGC GCGVLSIGTAMLGAGLCVGF DIDEDALEIFNRNAEEFELT NIDMVQCDVCLLSNRMSKSF DTVIMNPPFGTKNNKGTDMA FLKTALEMARTAVYSLHKSS TREHVQKKAAEWKIKIDIIA ELRYDLPASYKFHKKKSVDI EVDLIRFSF |
| Tissue Specificity | Expressed from very early development (8 post-conceptual weeks) and expression persists through adulthood in multiple substructures of the brain, including the cerebellar cortex, hippocampus, and striatum. |
| Function | Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA. N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation. |
| Protein Name | Rrna N6-Adenosine-Methyltransferase Mettl5Methyltransferase-Like Protein 5 |
| Cellular Localisation | NucleusPresynapsePostsynapse |
| Alternative Antibody Names | Anti-Rrna N6-Adenosine-Methyltransferase Mettl5 antibodyAnti-Methyltransferase-Like Protein 5 antibodyAnti-METTL5 antibodyAnti-DC3 antibodyAnti-HSPC133 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
