| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | METTL5 |
| Gene ID: | 29081 |
| Uniprot ID: | METL5_HUMAN |
| Immunogen Region: | 1-209 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-209 of human METTL5 (NP_054887.2). |
| Immunogen Sequence: | MKKVRLKELESRLQQVDGFE KPKLLLEQYPTRPHIAACML YTIHNTYDDIENKVVADLGC GCGVLSIGTAMLGAGLCVGF DIDEDALEIFNRNAEEFELT NIDMVQCDVCLLSNRMSKSF DTVIMNPPFGTKNNKGTDMA FLKTALEMARTAVYSLHKSS TREHVQKKAAEWKIKIDIIA ELRYDLPASYKFHKKKSVDI EVDLIRFSF |
| Tissue Specificity | Expressed from very early development (8 post-conceptual weeks) and expression persists through adulthood in multiple substructures of the brain, including the cerebellar cortex, hippocampus, and striatum. |
| Function | Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA. N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation. |
| Protein Name | Rrna N(6-Adenosine-Methyltransferase Mettl5Methyltransferase-Like Protein 5 |
| Cellular Localisation | NucleusPresynapsePostsynapse |
| Alternative Antibody Names | Anti-Rrna N(6-Adenosine-Methyltransferase Mettl5 antibodyAnti-Methyltransferase-Like Protein 5 antibodyAnti-METTL5 antibodyAnti-DC3 antibodyAnti-HSPC133 antibody |
Information sourced from Uniprot.org