Anti-COPS8 antibody (1-209) (STJ114618)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal COPS8 (1-209) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COPS8 |
| Gene ID | 10920 |
| Uniprot ID | CSN8_HUMAN |
| Immunogen Region | 1-209 |
| Immunogen Sequence | MPVAVMAESAFSFKKLLDQC ENQELEAPGGIATPPVYGQL LALYLLHNDMNNARYLWKRI PPAIKSANSELGGIWSVGQR IWQRDFPGIYTTINAHQWSE TVQPIMEALRDATRRRAFAL VSQAYTSIIADDFAAFVGLP VEEAVKGILEQGWQADSTTR MVLPRKPVAGALDVSFNKFI PLSEPAPVPPIPNEQQLARL TDYVAFLEN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-209 of human COPS8 (NP_006701.1). |
Additional Info
| Function | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
| Protein Name | Cop9 Signalosome Complex Subunit 8Sgn8Signalosome Subunit 8Cop9 HomologHcop9Jab1-Containing Signalosome Subunit 8 |
| Database Links | Reactome: R-HSA-5696394Reactome: R-HSA-6781823Reactome: R-HSA-8856825Reactome: R-HSA-8951664 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cop9 Signalosome Complex Subunit 8 antibodyAnti-Sgn8 antibodyAnti-Signalosome Subunit 8 antibodyAnti-Cop9 Homolog antibodyAnti-Hcop9 antibodyAnti-Jab1-Containing Signalosome Subunit 8 antibodyAnti-COPS8 antibodyAnti-CSN8 antibody |
Information sourced from Uniprot.org