| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | METTL2A |
| Gene ID: | 339175 |
| Uniprot ID: | MET2A_HUMAN |
| Immunogen Region: | 139-378 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 139-378 of human METTL2A (NP_859076.3). |
| Immunogen Sequence: | EQHKCSSKSLEHKTQTLPVE ENVTQKISDLEICADEFPGS SATYRILEVGCGVGNTVFPI LQTNNDPGLFVYCCDFSSTA IELVQTNSEYDPSRCFAFVH DLCDEEKSYPVPKGSLDIII LIFVLSAIVPDKMQKAINRL SRLLKPGGMMLLRDYGRYDM AQLRFKKGQCLSGNFYVRGD GTRVYFFTQEELDTLFTTAG LEKVQNLVDRRLQVNRGKQL TMYRVWIQCKYCKPLLSST |
| Function | S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). N(3)-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite. |
| Protein Name | Trna N(3-Cytidine Methyltransferase Mettl2aMethyltransferase-Like Protein 2a |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Trna N(3-Cytidine Methyltransferase Mettl2a antibodyAnti-Methyltransferase-Like Protein 2a antibodyAnti-METTL2A antibodyAnti-METTL2 antibodyAnti-HSPC266 antibody |
Information sourced from Uniprot.org