Anti-METTL2A antibody (139-378) (STJ116101)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal METTL2A (139-378) antibody for use in IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | METTL2A |
| Gene ID | 339175 |
| Uniprot ID | MET2A_HUMAN |
| Immunogen Region | 139-378 |
| Immunogen Sequence | EQHKCSSKSLEHKTQTLPVE ENVTQKISDLEICADEFPGS SATYRILEVGCGVGNTVFPI LQTNNDPGLFVYCCDFSSTA IELVQTNSEYDPSRCFAFVH DLCDEEKSYPVPKGSLDIII LIFVLSAIVPDKMQKAINRL SRLLKPGGMMLLRDYGRYDM AQLRFKKGQCLSGNFYVRGD GTRVYFFTQEELDTLFTTAG LEKVQNLVDRRLQVNRGKQL TMYRVWIQCKYCKPLLSST |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 139-378 of human METTL2A (NP_859076.3). |
Additional Info
| Function | S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). N(3)-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite. |
| Protein Name | Trna N(3-Cytidine Methyltransferase Mettl2aMethyltransferase-Like Protein 2a |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Trna N(3-Cytidine Methyltransferase Mettl2a antibodyAnti-Methyltransferase-Like Protein 2a antibodyAnti-METTL2A antibodyAnti-METTL2 antibodyAnti-HSPC266 antibody |
Information sourced from Uniprot.org