Anti-Metabotropic Glutamate Receptor Type 2/Type 3 antibody (STJA0040591)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenSynthetic peptides
General Information
| Short Description | Chicken polyclonal anti-Metabotropic Glutamate Receptor Type 2/Type 3 for use in IHC and ICC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ICC |
| Host | Chicken |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Concentration | 200 µg/mL |
| Purification | Affinity-Purified IgY |
| Dilution Range | IHC 1:1000-1:2000ICC 1:1000-1:2000 |
| Formulation | Phosphate-buffered (10 mM) isotonic (0.9%, w/v) saline (“PBS, pH 7.2) with sodium azide (0.02%, w/v) added as a preservative." |
| Storage Instruction | Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile. For longer term storage, aliquot and freeze to avoid freeze-thaw of the antibody. |
Target Information
| Gene Symbol | GRM2 |
| Gene ID | 2912 |
| Uniprot ID | GRM2_HUMAN |
| Immunogen | Synthetic peptides |
| Immunogen Sequence | Human, Mouse, Rat |
Additional Info
| Function | Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate. Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling. Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. (Microbial infection) Plays an important role in influenza virus internalization. (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of GRM2 to enter cells. (Microbial infection) Acts as a host entry factor for SARS-CoV-2 that hijacks the endocytosis of GRM2 to enter cells. |
| Protein Name | Metabotropic Glutamate Receptor 2Mglur2 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-420499 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSynapseCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Metabotropic Glutamate Receptor 2 antibodyAnti-Mglur2 antibodyAnti-GRM2 antibodyAnti-GPRC1B antibodyAnti-MGLUR2 antibody |
Information sourced from Uniprot.org