Anti-Metabotropic Glutamate Receptor 2 antibody [R04-2D1] (STJA0034561)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Metabotropic Glutamate Receptor 2
General Information
| Short Description | Rabbit monoclonal anti-Metabotropic Glutamate Receptor 2 for use in WB and IHC-P in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R04-2D1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | GRM2 |
| Gene ID | 2912 |
| Uniprot ID | GRM2_HUMAN |
| Immunogen | A synthetic peptide of human Metabotropic Glutamate Receptor 2 |
Additional Info
| Tissue Specificity | Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain. |
| Function | Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate. Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling. Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. (Microbial infection) Plays an important role in influenza virus internalization. (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of GRM2 to enter cells. (Microbial infection) Acts as a host entry factor for SARS-CoV-2 that hijacks the endocytosis of GRM2 to enter cells. |
| Protein Name | Metabotropic Glutamate Receptor 2Mglur2 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-420499 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSynapseCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Metabotropic Glutamate Receptor 2 antibodyAnti-Mglur2 antibodyAnti-GRM2 antibodyAnti-GPRC1B antibodyAnti-MGLUR2 antibody |
Information sourced from Uniprot.org