Anti-MEPE antibody (90-256) (STJ11103665)

Name: Anti-MEPE antibody (90-256) (STJ11103665)
SKU: STJ11103665
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11103665

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Short Description	Rabbit polyclonal MEPE (90-256) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	MEPE
Gene ID	56955
Uniprot ID	MEPE_HUMAN
Immunogen Region	90-256
Immunogen Sequence	FTNRQRLNKEYSISNKENTH NGLRMSIYPKSTGNKGFEDG DDAISKLHDQEEYGAALIRN NMQHIMGPVTAIKLLGEENK ENTPRNVLNIIPASMNYAKA HSKDKKKPQRDSQAQKSPVK SKSTHRIQHNIDYLKHLSKV KKIPSDFEGSGYTDLQERGD NDISPFS
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 90-256 of human MEPE (NP_064588.1).

Tissue Specificity	Detected in urine (at protein level). Expressed by osteoblasts. Expressed by stem cells in dental pulp. Expressed by mesenchymal cells in dental papilla and dental pulp. Expressed in teeth, specifically in decidious dentin. Expressed in ondotoblasts. Expressed in salivary glands. Secreted from oncogenic hypophosphatemic tumors.
Post Translational Modifications	Phosphorylated on serine residues in the ASARM motif (in vitro) by FAM20C.the phosphorylation is important for the inhibition of bone mineralization. Cleaved by CTSB/cathepsin B.the cleavage is blocked by metalloprotease PHEX.
Function	Promotes renal phosphate excretion and inhibits intestinal phosphate absorption. Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage. Promotes dental pulp stem cell proliferation and differentiation.
Protein Name	Matrix Extracellular Phosphoglycoprotein Osteoblast/Osteocyte Factor 45 Of45 Osteoregulin
Database Links	Reactome: R-HSA-381426 Reactome: R-HSA-8957275
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative Antibody Names	Anti-Matrix Extracellular Phosphoglycoprotein antibody Anti-Osteoblast/Osteocyte Factor 45 antibody Anti-Of45 antibody Anti-Osteoregulin antibody Anti-MEPE antibody

Information sourced from Uniprot.org