• STJ71326 (1µg/ml) staining of Rat Testis lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.

Anti-MEPCE antibody (Internal) (STJ71326)

SKU:
STJ71326-100

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Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-MEPCE (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-1-3µg/ml
IHC-5-10µg/ml
ELISA-antibody detection limit dilution 1:2000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: MEPCE
Gene ID: 56257
Uniprot ID: MEPCE_HUMAN
Immunogen Region: Internal
Accession Number: NP_062552.2
Immunogen Sequence: KQQRKFQYGNYCK
Function S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it. Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex. MEPCE has a non-enzymatic function in the 7SK RNP complex.interaction with LARP7 within the 7SK RNP complex occluding its catalytic center.
Protein Name 7sk Snrna Methylphosphate Capping Enzyme
Mepce
Bicoid-Interacting Protein 3 Homolog
Bin3 Homolog
Cellular Localisation Nucleus
Alternative Antibody Names Anti-7sk Snrna Methylphosphate Capping Enzyme antibody
Anti-Mepce antibody
Anti-Bicoid-Interacting Protein 3 Homolog antibody
Anti-Bin3 Homolog antibody
Anti-MEPCE antibody
Anti-BCDIN3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance