• Western blot analysis of various lysates using Menin Rabbit polyclonal antibody (STJ117485) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-MEN1 antibody (266-615) (STJ117485)

SKU:
STJ117485

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-MEN1 (266-615) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MEN1
Gene ID: 4221
Uniprot ID: MEN1_HUMAN
Immunogen Region: 266-615
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 266-615 of human Menin (NP_000235.2).
Immunogen Sequence: QKLLWLLYDLGHLERYPMAL GNLADLEELEPTPGRPDPLT LYHKGIASAKTYYRDEHIYP YMYLAGYHCRNRNVREALQA WADTATVIQDYNYCREDEEI YKEFFEVANDVIPNLLKEAA SLLEAGEERPGEQSQGTQSQ GSALQDPECFAHLLRFYDGI CKWEEGSPTPVLHVGWATFL VQSLGRFEGQVRQKVRIVSR EAEAAEAEEPWGEEAREGRR RGPRRESKPEEPPPPKKPA
Tissue Specificity Ubiquitous.
Function Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair.
Protein Name Menin
Database Links Reactome: R-HSA-201722
Reactome: R-HSA-2173796
Reactome: R-HSA-3769402
Reactome: R-HSA-381426
Reactome: R-HSA-5626467
Reactome: R-HSA-8957275
Reactome: R-HSA-9772755
Cellular Localisation Nucleus
Concentrated In Nuclear Body-Like Structures
Relocates To The Nuclear Matrix Upon Gamma Irradiation
Alternative Antibody Names Anti-Menin antibody
Anti-MEN1 antibody
Anti-SCG2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance