Anti-Melanocyte-stimulating hormone, alpha antibody (POMC) (STJA0040721)
SPECIFICATIONS
ClonalityPolyclonal
HostGuinea Pig
ConjugationUnconjugated
IsotypeMixed
ImmunogenA synthetic peptide (Ac-SYSMEHFRWGKPV) corresponding to the amino acids 138-150 from human Proopiomelanocortin (POMC). POMC is the precursor of the melanocortin peptides alpha, beta and gamma. The synthetic peptide was conjugated to a carrier protein
General Information
| Short Description | Guinea Pig polyclonal anti-Melanocyte-stimulating hormone, alpha (POMC) for use in IHC-F in Human, Rat and Sheep samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-F |
| Host | Guinea Pig |
| Reactivity | Human/Rat/Sheep |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | Mixed |
| Conjugation | Unconjugated |
| Purification | Whole serum |
| Dilution Range | IHC 1.4305555555555556 |
| Storage Instruction | Spin vial briefly before opening. Reconstitute in 50 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. Store lyophilized antibody at 2-8°C or lower. After reconstitution, divide into aliquots and store at-20°C, or low |
Target Information
| Gene Symbol | POMC |
| Gene ID | 5443 |
| Uniprot ID | COLI_HUMAN |
| Immunogen | A synthetic peptide (Ac-SYSMEHFRWGKPV) corresponding to the amino acids 138-150 from human Proopiomelanocortin (POMC). POMC is the precursor of the melanocortin peptides alpha, beta and gamma. The synthetic peptide was conjugated to a carrier protein |
| Immunogen Region | POMC |
| Immunogen Sequence | Human |
| Specificity | Specificity was demonstrated by immunohistochemistry. This antibody is known to react with human, rat and sheep. Other species have not yet been tested. |
Additional Info
| Tissue Specificity | ACTH and MSH are produced by the pituitary gland. |
| Post Translational Modifications | Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated.reducing sugar is probably N-acetylgalactosamine. |
| Function | Corticotropin: Stimulates the adrenal glands to release cortisol. Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes. Beta-endorphin: Endogenous orexigenic opiate. Met-enkephalin: Endogenous opiate. |
| Protein Name | Pro-OpiomelanocortinPomcCorticotropin-Lipotropin Cleaved Into - Npp - Melanotropin GammaGamma-Msh - Potential Peptide - CorticotropinAdrenocorticotropic HormoneActh - Melanocyte-Stimulating Hormone AlphaAlpha-MshMelanotropin Alpha - Corticotropin-Like Intermediary PeptideClip - Lipotropin BetaBeta-Lph - Lipotropin GammaGamma-Lph - Melanocyte-Stimulating Hormone BetaBeta-MshMelanotropin Beta - Beta-Endorphin - Met-Enkephalin |
| Database Links | Reactome: R-HSA-111885Reactome: R-HSA-193048Reactome: R-HSA-194002Reactome: R-HSA-202040Reactome: R-HSA-209952Reactome: R-HSA-211976Reactome: R-HSA-375276Reactome: R-HSA-418555Reactome: R-HSA-418594Reactome: R-HSA-5579031Reactome: R-HSA-6785807Reactome: R-HSA-9615017Reactome: R-HSA-9856649 |
| Cellular Localisation | SecretedMelanocyte-Stimulating Hormone Alpha And Beta-Endorphin Are Stored In Separate Granules In Hypothalamic Pomc NeuronsSuggesting That Secretion May Be Under The Control Of Different Regulatory Mechanisms |
| Alternative Antibody Names | Anti-Pro-Opiomelanocortin antibodyAnti-Pomc antibodyAnti-Corticotropin-Lipotropin Cleaved Into - Npp - Melanotropin Gamma antibodyAnti-Gamma-Msh - Potential Peptide - Corticotropin antibodyAnti-Adrenocorticotropic Hormone antibodyAnti-Acth - Melanocyte-Stimulating Hormone Alpha antibodyAnti-Alpha-Msh antibodyAnti-Melanotropin Alpha - Corticotropin-Like Intermediary Peptide antibodyAnti-Clip - Lipotropin Beta antibodyAnti-Beta-Lph - Lipotropin Gamma antibodyAnti-Gamma-Lph - Melanocyte-Stimulating Hormone Beta antibodyAnti-Beta-Msh antibodyAnti-Melanotropin Beta - Beta-Endorphin - Met-Enkephalin antibodyAnti-POMC antibody |
Information sourced from Uniprot.org