Anti-Melan-A/MART-1 antibody [SRM14511] (STJ11109241)

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STJ11109241
€142.20 - €625.80
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Short Description :Rabbit monoclonal Melan-A/MART-1 antibody for use in WB, IF, ICC, IHC-P and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/IF/ICC/IHC-P/ELISA
Host:Rabbit
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SRM14511
Isotype:IgG
Conjugation:Unconjugated
Purification:Affinity purification
Dilution Range:WB, 1:1000-1:5000
IF/ICC, 1:50-1:200
IHC, 1:1000-1:4000
ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:MLANA
Gene ID:2315
Uniprot ID:MAR1_HUMAN
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Tissue Specificity Expression is restricted to melanoma and melanocyte cell lines and retina.
Post Translational Modifications Acylated.
Function Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Protein Name Melanoma Antigen Recognized By T-Cells 1
Mart-1
Antigen Lb39-Aa
Antigen Sk29-Aa
Protein Melan-A
Database Links Reactome: R-HSA-9824585
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Iii Membrane Protein
Golgi Apparatus
Trans-Golgi Network Membrane
Melanosome
Also Found In Small Vesicles And Tubules Dispersed Over The Entire Cytoplasm
A Small Fraction Of The Protein Is Inserted Into The Membrane In An Inverted Orientation
Inversion Of Membrane Topology Results In The Relocalization Of The Protein From A Predominant Golgi/Post-Golgi Area To The Endoplasmic Reticulum
Melanoma Cells Expressing The Protein With An Inverted Membrane Topology Are More Effectively Recognized By Specific Cytolytic T-Lymphocytes Than Those Expressing The Protein In Its Native Membrane Orientation
Alternative Antibody Names Anti-Melanoma Antigen Recognized By T-Cells 1 antibody
Anti-Mart-1 antibody
Anti-Antigen Lb39-Aa antibody
Anti-Antigen Sk29-Aa antibody
Anti-Protein Melan-A antibody
Anti-MLANA antibody
Anti-MART1 antibody

Information sourced from Uniprot.org

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