Anti-MEK3 antibody [SRM13596] (STJ11108326)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM13596 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB, 1:1000-1:4000IF/ICC, 1:50-1:200ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAP2K3 |
| Gene ID | 5606 |
| Uniprot ID | MP2K3_HUMAN |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
| Immunogen Sequence | Human |
Additional Info
| Post Translational Modifications | Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases positively regulates the kinase activity. Phosphorylated by TAOK2. (Microbial infection) Yersinia YopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway. |
| Function | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. |
| Protein Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 3Map Kinase Kinase 3Mapkk 3Mapk/Erk Kinase 3Mek 3Stress-Activated Protein Kinase Kinase 2Sapk Kinase 2Sapkk-2Sapkk2 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-450302Reactome: R-HSA-5210891 P46734-3 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 antibodyAnti-Map Kinase Kinase 3 antibodyAnti-Mapkk 3 antibodyAnti-Mapk/Erk Kinase 3 antibodyAnti-Mek 3 antibodyAnti-Stress-Activated Protein Kinase Kinase 2 antibodyAnti-Sapk Kinase 2 antibodyAnti-Sapkk-2 antibodyAnti-Sapkk2 antibodyAnti-MAP2K3 antibodyAnti-MEK3 antibodyAnti-MKK3 antibodyAnti-PRKMK3 antibodyAnti-SKK2 antibody |
Information sourced from Uniprot.org