| Short Description : | Rabbit monoclonal anti-MEIS1 for use in WB, IP and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IP/FC |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | R04-7E4 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | Affinity Chromatography |
| Dilution Range: | WB 1:500-1:1000IP 1:50FC 1:50-1:100 |
| Formulation: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | MEIS1 |
| Gene ID: | 4211 |
| Uniprot ID: | MEIS1_HUMAN |
| Immunogen: | A synthesized peptide derived from human MEIS1 |
| Tissue Specificity | Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum. |
| Function | Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. |
| Protein Name | Homeobox Protein Meis1 |
| Database Links | Reactome: R-HSA-5617472 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Meis1 antibodyAnti-MEIS1 antibody |
Information sourced from Uniprot.org
