Anti-MED12 antibody (1981-1994) (STJ72605)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-MED12 (1981-1994) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments gave an approx 70kDa band in Human Brain (Olfactory Bulb) and Rat Brain lysates after 0.5µg/ml antibody staining. Please note that currently we cannot find an e |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | MED12 |
| Gene ID | 9968 |
| Uniprot ID | MED12_HUMAN |
| Accession Number | NP_005111.2 |
| Immunogen Region | 1981-1994 |
| Immunogen Sequence | NPTLVDPTRHLQQR |
Additional Info
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Protein Name | Mediator Of Rna Polymerase Ii Transcription Subunit 12Activator-Recruited Cofactor 240 Kda ComponentArc240Cag Repeat Protein 45Mediator Complex Subunit 12Opa-Containing ProteinThyroid Hormone Receptor-Associated Protein Complex 230 Kda ComponentTrap230Trinucleotide Repeat-Containing Gene 11 Protein |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-212436Reactome: R-HSA-381340Reactome: R-HSA-9833110 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Mediator Of Rna Polymerase Ii Transcription Subunit 12 antibodyAnti-Activator-Recruited Cofactor 240 Kda Component antibodyAnti-Arc240 antibodyAnti-Cag Repeat Protein 45 antibodyAnti-Mediator Complex Subunit 12 antibodyAnti-Opa-Containing Protein antibodyAnti-Thyroid Hormone Receptor-Associated Protein Complex 230 Kda Component antibodyAnti-Trap230 antibodyAnti-Trinucleotide Repeat-Containing Gene 11 Protein antibodyAnti-MED12 antibodyAnti-ARC240 antibodyAnti-CAGH45 antibodyAnti-HOPA antibodyAnti-KIAA0192 antibodyAnti-TNRC11 antibodyAnti-TRAP230 antibody |
Information sourced from Uniprot.org