| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Protein Name | Mediator Of Rna Polymerase Ii Transcription Subunit 12Activator-Recruited Cofactor 240 Kda ComponentArc240Cag Repeat Protein 45Mediator Complex Subunit 12Opa-Containing ProteinThyroid Hormone Receptor-Associated Protein Complex 230 Kda ComponentTrap230Trinucleotide Repeat-Containing Gene 11 Protein |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-212436Reactome: R-HSA-381340Reactome: R-HSA-9833110 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Mediator Of Rna Polymerase Ii Transcription Subunit 12 antibodyAnti-Activator-Recruited Cofactor 240 Kda Component antibodyAnti-Arc240 antibodyAnti-Cag Repeat Protein 45 antibodyAnti-Mediator Complex Subunit 12 antibodyAnti-Opa-Containing Protein antibodyAnti-Thyroid Hormone Receptor-Associated Protein Complex 230 Kda Component antibodyAnti-Trap230 antibodyAnti-Trinucleotide Repeat-Containing Gene 11 Protein antibodyAnti-MED12 antibodyAnti-ARC240 antibodyAnti-CAGH45 antibodyAnti-HOPA antibodyAnti-KIAA0192 antibodyAnti-TNRC11 antibodyAnti-TRAP230 antibody |
Information sourced from Uniprot.org
