Anti-MECR antibody (160-210 aa) (STJ195034)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human MECR at the amino acid range 160-210
General Information
| Short Description | Rabbit polyclonal anti-Enoyl-acyl-carrier-protein reductase, mitochondrial (160-210 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MECR |
| Gene ID | 51102 |
| Uniprot ID | MECR_HUMAN |
| Immunogen | Synthesized peptide derived from the human MECR at the amino acid range 160-210 |
| Immunogen Region | 160-210 aa |
| Specificity | This antibody detects endogenous levels of MECR at Human/Mouse/Rat |
Additional Info
| Function | Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates. May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells. Involved in iron homeostasis.affecting Fe-S cluster assembly and ceramide metabolism. Required for proper morphology and bioenergetic functions of mitochondria. Required for maintenance of neurons. |
| Protein Name | Enoyl-Acyl-Carrier-Protein Reductase - Mitochondrial2-Enoyl Thioester ReductaseNuclear Receptor-Binding Factor 1Hsnrbf-1Nrbf-1 |
| Database Links | Reactome: R-HSA-77346 |
| Cellular Localisation | Isoform 1: MitochondrionIsoform 2: CytoplasmNucleus |
| Alternative Antibody Names | Anti-Enoyl-Acyl-Carrier-Protein Reductase - Mitochondrial antibodyAnti-2-Enoyl Thioester Reductase antibodyAnti-Nuclear Receptor-Binding Factor 1 antibodyAnti-Hsnrbf-1 antibodyAnti-Nrbf-1 antibodyAnti-MECR antibodyAnti-NBRF1 antibodyAnti-CGI-63 antibody |
Information sourced from Uniprot.org