Anti-MeCP2 isoform 1 antibody (1-50) {FITC} (STJ501743)

Name: Anti-MeCP2 isoform 1 antibody (1-50) {FITC} (STJ501743)
SKU: STJ501743-100
Price: 597 EUR
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationFITC

IsotypeIgG

ImmunogenSynthetic peptide taken within amino acid region 1-50 on mouse methyl-CpG-binding protein 2 isoform 1.

STJ501743-100

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Short Description	Rabbit polyclonal antibody anti-MeCP2 isoform 1 (1-50) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Applications	ELISA/IP/WB
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	FITC
Concentration	0.5-1.5 µg/µl
Purification	Affinity Purified
Dilution Range	WB: 1:2, 500-1:5, 000 ELISA: 1:50, 000 IP: 1:200
Formulation	Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	MECP2
Gene ID	4204
Uniprot ID	MECP2_HUMAN
Immunogen	Synthetic peptide taken within amino acid region 1-50 on mouse methyl-CpG-binding protein 2 isoform 1.
Immunogen Region	1-50

Tissue Specificity	Present in all adult somatic tissues tested.
Post Translational Modifications	Phosphorylated on Ser-423 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation.
Function	Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Protein Name	Methyl-Cpg-Binding Protein 2 Mecp-2 Protein Mecp2
Database Links	Reactome: R-HSA-8986944 Reactome: R-HSA-9022534 Reactome: R-HSA-9022535 Reactome: R-HSA-9022537 Reactome: R-HSA-9022538 Reactome: R-HSA-9022692 Reactome: R-HSA-9022699 Reactome: R-HSA-9022702 Reactome: R-HSA-9022707 Reactome: R-HSA-9022927 Reactome: R-HSA-9725371
Cellular Localisation	Nucleus Colocalized With Methyl-Cpg In The Genome Colocalized With Tbl1x To The Heterochromatin Foci
Alternative Antibody Names	Anti-Methyl-Cpg-Binding Protein 2 antibody Anti-Mecp-2 Protein antibody Anti-Mecp2 antibody Anti-MECP2 antibody

Information sourced from Uniprot.org