Anti-MDR antibody [M2I-4] (STJ16100891)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogencMOAB/MRP2 amino acids 215-310
General Information
| Short Description | Mouse monoclonal anti-MDR for use in ICC, IHC-F, FC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ICC/IHC-F/FC/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | M2I-4 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 250 Mu g/mL |
| Dilution Range | ICCIHC-F 1:20FCWB 1:20 |
| Formulation | Serum free tissue culture supernatant with 07% BSA and 0.1% sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Immunogen | cMOAB/MRP2 amino acids 215-310 |
Additional Info
| Background | M2I-4 reacts with an internal epitope of cMOAT/MRP2, a 170-180 kD transmembrane protein known as the canalicular multi-organic anion transporter, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. cMOAT/MRP2 is closely related to the multidrug resistance related protein MRP, and cMOAT/MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. M2I-4 was raised against a bacterial fusion protein of cMOAB/MRP2, containing amino acids 215-310 of the protein. M2I-4 did not cross react with the human MDR1, MRP1, MRP3 and MRP5 gene products. |
Information sourced from Uniprot.org