![Anti-MDM4 nanobody [SAA1189] (STJN000040)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200653/412835/STJN000040-SDS-PAGE-1__06289.1749232385.jpg?c=1 "Anti-MDM4 nanobody [SAA1189] (STJN000040)")
![Anti-MDM4 nanobody [SAA1189] (STJN000040)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200653/412835/STJN000040-SDS-PAGE-1__06289.1749232385.jpg?c=1 "Anti-MDM4 nanobody [SAA1189] (STJN000040)")
Anti-MDM4 nanobody [SAA1189] (STJN000040)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Protein Mdm4 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1189 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | MDM4 |
| Gene ID | 4194 |
| Uniprot ID | MDM4_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylated. Phosphorylation at Ser-367 promotes interaction with YWHAG and subsequent ubiquitination and degradation. Phosphorylation at Ser-342 also induces ubiquitination and degradation but to a lower extent. Ubiquitinated and degraded by MDM2. Deubiquitination by USP2 on the other hand stabilizes the MDM4 protein. |
| Function | Along with MDM2, contributes to TP53 regulation. Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. |
| Protein Name | Protein Mdm4Double Minute 4 ProteinMdm2-Like P53-Binding ProteinProtein MdmxP53-Binding Protein Mdm4 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-2559585Reactome: R-HSA-5689880Reactome: R-HSA-6804756Reactome: R-HSA-6804757Reactome: R-HSA-6804760Reactome: R-HSA-69541 |
| Cellular Localisation | Nucleus |
| Alternative Nanobody Names | Anti-Protein Mdm4 nanobodyAnti-Double Minute 4 Protein nanobodyAnti-Mdm2-Like P53-Binding Protein nanobodyAnti-Protein Mdmx nanobodyAnti-P53-Binding Protein Mdm4 nanobodyAnti-MDM4 nanobodyAnti-MDMX nanobody |
Information sourced from Uniprot.org