| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-MDG1/DNAJB9 (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-4-6µg/mlELISA-antibody detection limit dilution 1:4000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
DNAJB9 |
| Gene ID: |
4189 |
| Uniprot ID: |
DNJB9_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_036460.1 |
| Immunogen Sequence: |
RGNMVTTYTDCSGQ |
| Function | Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production. |
| Protein Name | Dnaj Homolog Subfamily B Member 9Endoplasmic Reticulum Dna J Domain-Containing Protein 4Er-Resident Protein Erdj4Erdj4Microvascular Endothelial Differentiation Gene 1 ProteinMdg-1 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily B Member 9 antibodyAnti-Endoplasmic Reticulum Dna J Domain-Containing Protein 4 antibodyAnti-Er-Resident Protein Erdj4 antibodyAnti-Erdj4 antibodyAnti-Microvascular Endothelial Differentiation Gene 1 Protein antibodyAnti-Mdg-1 antibodyAnti-DNAJB9 antibodyAnti-MDG1 antibodyAnti-UNQ743 antibodyAnti-PRO1471 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
