| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ER degradation-enhancing alpha-mannosidase-like protein 2 (C-Term) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EDEM2 |
| Gene ID: |
55741 |
| Uniprot ID: |
EDEM2_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
EDEM2 Polyclonal Antibody detects endogenous levels of EDEM2 protein. |
| Immunogen: |
Synthesized peptide derived from the C-terminal region of human EDEM2. |
| Post Translational Modifications | N-glycosylated. |
| Function | Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins. |
| Protein Name | Er Degradation-Enhancing Alpha-Mannosidase-Like Protein 2 |
| Database Links | Reactome: R-HSA-901032Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Er Degradation-Enhancing Alpha-Mannosidase-Like Protein 2 antibodyAnti-EDEM2 antibodyAnti-C20orf31 antibodyAnti-C20orf49 antibodyAnti-UNQ573 antibodyAnti-PRO1135 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
