| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MCOLN2 (90-275) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MCOLN2 |
| Gene ID: |
255231 |
| Uniprot ID: |
MCLN2_HUMAN |
| Immunogen Region: |
90-275 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 90-275 of human MCOLN2 (NP_694991.2). |
| Immunogen Sequence: |
VVAFKEDNTVAFKHLFLKGY SGTDEDDYSCSVYTQEDAYE SIFFAINQYHQLKDITLGTL GYGENEDNRIGLKVCKQHYK KGTMFPSNETLNIDNDVELD CVQLDLQDLSKKPPDWKNSS FFRLEFYRLLQVEISFHLKG IDLQTIHSRELPDCYVFQNT IIFDNKAHSGKIKIYFDSDA KIEECK |
| Function | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway. May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells. In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. |
| Protein Name | Mucolipin-2Transient Receptor Potential Channel Mucolipin 2Trpml2 |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLate Endosome MembraneLysosome MembraneRecycling Endosome MembraneLocalizes To Recycling Endosomes In Activated Macrophages And Microglia |
| Alternative Antibody Names | Anti-Mucolipin-2 antibodyAnti-Transient Receptor Potential Channel Mucolipin 2 antibodyAnti-Trpml2 antibodyAnti-MCOLN2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
