Anti-MCOLN2 antibody (90-275) (STJ11100511)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MCOLN2 (90-275) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MCOLN2 |
| Gene ID | 255231 |
| Uniprot ID | MCLN2_HUMAN |
| Immunogen Region | 90-275 |
| Immunogen Sequence | VVAFKEDNTVAFKHLFLKGY SGTDEDDYSCSVYTQEDAYE SIFFAINQYHQLKDITLGTL GYGENEDNRIGLKVCKQHYK KGTMFPSNETLNIDNDVELD CVQLDLQDLSKKPPDWKNSS FFRLEFYRLLQVEISFHLKG IDLQTIHSRELPDCYVFQNT IIFDNKAHSGKIKIYFDSDA KIEECK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 90-275 of human MCOLN2 (NP_694991.2). |
Additional Info
| Function | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway. May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells. In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Also functions as a Fe(2+) permeable channel. |
| Protein Name | Mucolipin-2Transient Receptor Potential Channel Mucolipin 2Trpml2 |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLate Endosome MembraneLysosome MembraneRecycling Endosome MembraneLocalizes To Recycling Endosomes In Activated Macrophages And Microglia |
| Alternative Antibody Names | Anti-Mucolipin-2 antibodyAnti-Transient Receptor Potential Channel Mucolipin 2 antibodyAnti-Trpml2 antibodyAnti-MCOLN2 antibody |
Information sourced from Uniprot.org