Anti-MCMBP antibody (1-240) (STJ24530)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MCMBP (1-240) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MCMBP |
| Gene ID | 79892 |
| Uniprot ID | MCMBP_HUMAN |
| Immunogen Region | 1-240 |
| Immunogen Sequence | MPCGEDWLSHPLGIVQGFFA QNGVNPDWEKKVIEYFKEKL KENNAPKWVPSLNEVPLHYL KPNSFVKFRCMIQDMFDPEF YMGVYETVNQNTKAHVLHFG KYRDVAECGPQQELDLNSPR NTTLERQTFYCVPVPGESTW VKEAYVNANQARVSPSTSYT PSRHKRSYEDDDDMDLQPNK QKDQHAGARQAGSVGGLQWC GEPKRLETEASTGQQLNSLN LSSPFDLNFPLPGEKGPAC |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human MCMBP (NP_079110.1). |
Additional Info
| Function | Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP.probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. |
| Protein Name | Mini-Chromosome Maintenance Complex-Binding ProteinMcm-BpMcm-Binding Protein |
| Database Links | |
| Cellular Localisation | NucleusAssociates With ChromatinHighly Associated With Chromatin In G1/S And S PhasesReduced Binding To Chromatin In G2And Further Decreased Binding In Early M PhaseIt Then Reassociates With Chromatin In Late M PhaseDissociates From Chromatin Later Than Component Of The Mcm Complex |
| Alternative Antibody Names | Anti-Mini-Chromosome Maintenance Complex-Binding Protein antibodyAnti-Mcm-Bp antibodyAnti-Mcm-Binding Protein antibodyAnti-MCMBP antibodyAnti-C10orf119 antibody |
Information sourced from Uniprot.org