Anti-MCM10 antibody (616-875) (STJ116280)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MCM10 (616-875) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MCM10 |
| Gene ID | 55388 |
| Uniprot ID | MCM10_HUMAN |
| Immunogen Region | 616-875 |
| Immunogen Sequence | RLEGAPATMTPKLGRGVLEG DDVLFYDESPPPRPKLSALA EAKKLAAITKLRAKGQVLTK TNPNSIKKKQKDPQDILEVK ERVEKNTMFSSQAEDELEPA RKKRREQLAYLESEEFQKIL KAKSKHTGILKEAEAEMQER YFEPLVKKEQMEEKMRNIRE VKCRVVTCKTCAYTHFKLLE TCVSEQHEYHWHDGVKRFFK CPCGNRSISLDRLPNKHCSN CGLYKWERDGMLKEKTGPK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 616-875 of human MCM10 (NP_877428.1). |
Additional Info
| Function | Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability.acts as a direct target of transcriptional repression by ZBTB38. |
| Protein Name | Protein Mcm10 HomologHsmcm10 |
| Database Links | Reactome: R-HSA-176187Reactome: R-HSA-68962 |
| Cellular Localisation | NucleusColocalizes With Orc2 In Nuclei FociAssociated With Chromatin In S PhaseFrom Early To Mid-S Phase Located In Discrete Nuclear FociIn Early S PhaseSeveral Hundred Foci Appeared Throughout The NucleusIn Mid-S PhaseThe Foci Appeared At The Nuclear Periphery And Nucleolar RegionsIn The Late S And G Phases Localized To Nucleoli |
| Alternative Antibody Names | Anti-Protein Mcm10 Homolog antibodyAnti-Hsmcm10 antibodyAnti-MCM10 antibodyAnti-PRO2249 antibody |
Information sourced from Uniprot.org