![Anti-MC4R nanobody [SAA1276] (STJN000200)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200813/412995/STJN000200-SDS-PAGE-1__86547.1749232517.jpg?c=1 "Anti-MC4R nanobody [SAA1276] (STJN000200)")
![Anti-MC4R nanobody [SAA1276] (STJN000200)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200813/412995/STJN000200-SDS-PAGE-1__86547.1749232517.jpg?c=1 "Anti-MC4R nanobody [SAA1276] (STJN000200)")
Anti-MC4R nanobody [SAA1276] (STJN000200)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Melanocortin Receptor 4 is suitable for use in ELISA and RIA research applications. |
| Applications | ELISA/RIA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1276 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | MC4R |
| Gene ID | 4160 |
| Uniprot ID | MC4R_HUMAN |
Additional Info
| Function | Hormone receptor that acts as a key component of the leptin-melanocortin pathway at the intersection of homeostatic maintenance of energetic state. Plays a role in regulating food intake: activation by a stimulating hormone such as anorexigenic alpha-melanocyte stimulating hormone (alpha-MSH) inhibits appetite, whereas binding to a natural antagonist like Agouti-related protein/AGRP promotes appetite. G-protein-coupled receptor that activates conventional Galphas signaling leading to induction of anorexogenic signaling in the hypothalamus to result in negative energy balance. Regulates the firing activity of neurons from the hypothalamus by alpha-MSH and AGRP independently of Galphas signaling by ligand-induced coupling of closure of inwardly rectifying potassium channel KCNJ13. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via nesfatin-1/NUCB2 leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion in the intestinal epithelium. |
| Protein Name | Melanocortin Receptor 4Mc4-R |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418555Reactome: R-HSA-9856649 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Nanobody Names | Anti-Melanocortin Receptor 4 nanobodyAnti-Mc4-R nanobodyAnti-MC4R nanobody |
Information sourced from Uniprot.org