Anti-MC2R antibody (60-110 aa) (STJ13101422)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 60-110 of extracellular domain of human MC2R conjugated to blue carrier protein was used as the antigen. The peptide shares 85% identity with mouse sequence.
General Information
| Short Description | Rabbit polyclonal anti-MC2R (60-110 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | MC2R |
| Gene ID | 4158 |
| Uniprot ID | ACTHR_HUMAN |
| Immunogen | A synthetic peptide from aa region 60-110 of extracellular domain of human MC2R conjugated to blue carrier protein was used as the antigen. The peptide shares 85% identity with mouse sequence. |
| Immunogen Region | 60-110 aa |
| Specificity | Specific for MC2R. |
Additional Info
| Post Translational Modifications | Ubiquitinated by MGRN1 that may be involved in post-endocytic trafficking and/or degradation of internalized receptor. |
| Function | Hormone receptor primarily expressed in adrenal cortex that plays a key role in regulating adrenocortical function. Upon corticotropin (ACTH) binding, facilitates the release of adrenal glucocorticoids, including cortisol and corticosterone. In addition, MC2R is required for fetal and neonatal adrenal gland development. Mechanistically, activates adenylate cyclase (cAMP), the MAPK cascade as well as the cAMP-dependent protein kinase A pathway leading to steroidogenic factor 1/NR5A1-mediated transcriptional activation. |
| Protein Name | Adrenocorticotropic Hormone ReceptorActh ReceptorActh-RAdrenocorticotropin ReceptorMelanocortin Receptor 2Mc2-R |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418555Reactome: R-HSA-5579031 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Adrenocorticotropic Hormone Receptor antibodyAnti-Acth Receptor antibodyAnti-Acth-R antibodyAnti-Adrenocorticotropin Receptor antibodyAnti-Melanocortin Receptor 2 antibodyAnti-Mc2-R antibodyAnti-MC2R antibodyAnti-ACTHR antibody |
Information sourced from Uniprot.org