Anti-MC2R antibody (1-100) (STJ24517)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MC2R (1-100) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MC2R |
| Gene ID | 4158 |
| Uniprot ID | ACTHR_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MKHIINSYENINNTARNNSD CPRVVLPEEIFFTISIVGVL ENLIVLLAVFKNKNLQAPMY FFICSLAISDMLGSLYKILE NILIILRNMGYLKPRGSFET |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human MC2R (NP_000520.1) |
Additional Info
| Tissue Specificity | Melanocytes and corticoadrenal tissue. |
| Post Translational Modifications | Ubiquitinated by MGRN1 that may be involved in post-endocytic trafficking and/or degradation of internalized receptor. |
| Function | Hormone receptor primarily expressed in adrenal cortex that plays a key role in regulating adrenocortical function. Upon corticotropin (ACTH) binding, facilitates the release of adrenal glucocorticoids, including cortisol and corticosterone. In addition, MC2R is required for fetal and neonatal adrenal gland development. Mechanistically, activates adenylate cyclase (cAMP), the MAPK cascade as well as the cAMP-dependent protein kinase A pathway leading to steroidogenic factor 1/NR5A1-mediated transcriptional activation. |
| Protein Name | Adrenocorticotropic Hormone ReceptorActh ReceptorActh-RAdrenocorticotropin ReceptorMelanocortin Receptor 2Mc2-R |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418555Reactome: R-HSA-5579031 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Adrenocorticotropic Hormone Receptor antibodyAnti-Acth Receptor antibodyAnti-Acth-R antibodyAnti-Adrenocorticotropin Receptor antibodyAnti-Melanocortin Receptor 2 antibodyAnti-Mc2-R antibodyAnti-MC2R antibodyAnti-ACTHR antibody |
Information sourced from Uniprot.org