| Short Description : | Rabbit polyclonal anti-MC1R (2-50 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC/WB |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. |
| Formulation: | Lyophilised |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | MC1R |
| Gene ID: | 4157 |
| Uniprot ID: | MSHR_HUMAN |
| Immunogen: | A synthetic peptide from aa region 2-50 of extracellular domain of human MC1R conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region: | 2-50 aa |
| Specificity: | Specific for MC1R. |
| Function | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. |
| Protein Name | Melanocyte-Stimulating Hormone ReceptorMsh-RMelanocortin Receptor 1Mc1-R |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418555Reactome: R-HSA-9856649 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Melanocyte-Stimulating Hormone Receptor antibodyAnti-Msh-R antibodyAnti-Melanocortin Receptor 1 antibodyAnti-Mc1-R antibodyAnti-MC1R antibodyAnti-MSHR antibody |
Information sourced from Uniprot.org
