| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Muscleblind-like protein 1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MBNL1 |
| Gene ID: |
4154 |
| Uniprot ID: |
MBNL1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of MBNL1 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human MBNL1 |
| Function | Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues. |
| Protein Name | Muscleblind-Like Protein 1Triplet-Expansion Rna-Binding Protein |
| Cellular Localisation | NucleusCytoplasmCytoplasmic GranuleLocalized With Ddx1Tial1 And Ybx1 In Stress Granules Upon StressLocalized In The Cytoplasm Of Multinucleated MyotubesColocalizes With Nuclear Foci Of Retained Expanded-Repeat Transcripts In Myotubes From Patients Affected By Myotonic Dystrophy |
| Alternative Antibody Names | Anti-Muscleblind-Like Protein 1 antibodyAnti-Triplet-Expansion Rna-Binding Protein antibodyAnti-MBNL1 antibodyAnti-EXP antibodyAnti-KIAA0428 antibodyAnti-MBNL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
