| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-MBL2/Mannan-Binding Lectin (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx 26kDa band observed in Human Heart and Liver lysates (calculated MW of 26.1kDa according to NP_000233). Recommended concentration: 1-3µg/ml. Primary incubation 1 hour at room tem |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | MBL2 |
| Gene ID: | 4153 |
| Uniprot ID: | MBL2_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_000233.1 |
| Immunogen Sequence: | STSHLAVCEFPI |
| Function | Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. |
| Protein Name | Mannose-Binding Protein CMbp-CCollectin-1Mbp1Mannan-Binding ProteinMannose-Binding Lectin |
| Database Links | Reactome: R-HSA-166662Reactome: R-HSA-166663Reactome: R-HSA-9705671 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Mannose-Binding Protein C antibodyAnti-Mbp-C antibodyAnti-Collectin-1 antibodyAnti-Mbp1 antibodyAnti-Mannan-Binding Protein antibodyAnti-Mannose-Binding Lectin antibodyAnti-MBL2 antibodyAnti-COLEC1 antibodyAnti-MBL antibody |
Information sourced from Uniprot.org