Anti-MBL2 antibody (21-70 aa) (STJ98651)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide from the human protein at the amino acid range 21-70
General Information
| Short Description | Rabbit polyclonal anti-Mannose-binding protein C (21-70 aa) for use in WB and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MBL2 |
| Gene ID | 4153 |
| Uniprot ID | MBL2_HUMAN |
| Immunogen | Synthetic peptide from the human protein at the amino acid range 21-70 |
| Immunogen Region | 21-70 aa |
| Specificity | The antibody detects endogenous MBL-C protein |
Additional Info
| Function | Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. |
| Protein Name | Mannose-Binding Protein CMbp-CCollectin-1Mbp1Mannan-Binding ProteinMannose-Binding Lectin |
| Database Links | Reactome: R-HSA-166662Reactome: R-HSA-166663Reactome: R-HSA-9705671 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Mannose-Binding Protein C antibodyAnti-Mbp-C antibodyAnti-Collectin-1 antibodyAnti-Mbp1 antibodyAnti-Mannan-Binding Protein antibodyAnti-Mannose-Binding Lectin antibodyAnti-MBL2 antibodyAnti-COLEC1 antibodyAnti-MBL antibody |
Information sourced from Uniprot.org